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  • 產(chǎn)品名稱：兔抗TFEB多克隆抗體

  • 產(chǎn)品型號：100ul
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：1560
  • 產(chǎn)品庫存：60
  • 產(chǎn)品文檔：
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上海通蔚生物科研實(shí)驗(yàn)所需的ELISA試劑盒，培養(yǎng)基，抗體，動物血清血漿，標(biāo)準(zhǔn)品對照品，化學(xué)試劑，ELISA種屬涵蓋廣，憑借多年行業(yè)經(jīng)驗(yàn)，完善的售后服務(wù)，高質(zhì)量的產(chǎn)品，贏得客戶一致好評，兔抗TFEB多克隆抗體歡迎來電咨詢與訂購！
詳情介紹：

中文名稱：  兔抗TFEB多克隆抗體  

英文名稱： Anti-TFEB rabbit polyclonal antibody

別      名： transcription factor EB; TCFEB; BHLHE35; ALPHATFEB

相關(guān)類別： 一抗

儲      存： 冷凍（-20℃）

宿      主： Rabbit

抗      原： TFEB

反應(yīng)種屬： Human, Mouse

標(biāo) 記 物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

Background:

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937).

Applications:

ELISA, IHC

Name of antibody:

TFEB

Immunogen:

Fusion protein of human TFEB

Full name:

transcription factor EB

Synonyms:

TCFEB; BHLHE35; ALPHATFEB

SwissProt:

P19484

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human gastric cancer

IHC Recommend dilution:

50-200





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